反应详情

A solution of dimethyl oxaldiimidate (48 parts) in methanol (80 parts) was added to a slurry of 4-chloro-o-phenylenediamine (56 parts) in 0.3% aqueous hydrochloric acid (60 parts). The temperature rose to 54°. The reaction mixture was cooled and filtered to give a brown solid. After washing with THF, 61.4 parts of tan solid remained (80%). Recrystallization from THF or dioxane gave light-yellow crystals of 6-chloro-2,3-diaminoquinoxaline, m.p. 300°-303°.

1. customrose to 54°
2. temperatureThe reaction mixture was cooled
3. filtrationfiltered
4. customto give a brown solid
5. washAfter washing with THF, 61.4 parts of tan solid
6. customRecrystallization from THF or dioxane