反应详情

To a suspension of sodium hydride (from 7.2 gms., 0.15 mole 50% sodium hydride dispersed in mineral oil) in 125 ml fresh dimethyl formamide (DMF) is added ethyl 3-phenyl-5-chloroindole-2-carboxylate (45 gms, 0.15 mole), as a dry powder, in portions. The reaction is exothermic and requires a water bath to maintain the temperature between 45°-50° C. After stirring 15-20 minutes (at 35° C), chloroacetonitrile (12 grams, 0.15 mole) in 25 ml DMF is added slowly. The temperature rises to 45° C and the mixture is stirred overnight at ambient temperature. The mixture is then transferred to a one liter beaker and 500 ml of ice-water is added slowly. After 15-20 minutes the product is filtered off, washed well with water, and dried on a Buchner funnel. After recrystallization from ethanol the product gives a m.p. of 117°-19° C. There is obtained a total of 46 grams (90.2%), of sufficient purity for the next step. A sample is recrystallized from aqueous ethanol, washed with water and vacuum dried, m.p. 119°-120° C.

1. temperatureto maintain the temperature between 45°-50° C
2. additionis added slowly
3. customrises to 45° C
4. additionis added slowly
5. filtrationAfter 15-20 minutes the product is filtered off
6. washwashed well with water
7. customdried on a Buchner funnel
8. customAfter recrystallization from ethanol the product
9. customgives a m.p. of 117°-19° C
10. customThere is obtained a total of 46 grams (90.2%)
11. customA sample is recrystallized from aqueous ethanol
12. washwashed with water and vacuum
13. customdried