2-Amino-3-Hydroxypyridine → HCID 796646, compound

HRID 2397847Notes

Reaction equation

HRID 2397847 reaction equation
[NH2:1][C:2]1[C:7]([OH:8])=[CH:6][CH:5]=[CH:4][N:3]=1.N/[C:10](=[CH:15]\[CH3:16])/[C:11](OC)=[O:12]>>[OH:8][C:7]1[C:2]2=[N:1][C:15]([CH3:16])=[CH:10][C:11](=[O:12])[N:3]2[CH:4]=[CH:5][CH:6]=1

Participants

3

Reactant 2

HCID 281142-Amino-3-HydroxypyridineHCID 12743422HCID 12743422, compound

Product 1

HCID 796646HCID 796646, compoundYield 79.6%

Procedure

A mixture of 110.0 g of 2-amino-3-pyridinol and 130.0 g of methyl 2-aminocrotonate are heated at an internal temperature of 110°-115° for approximately 4 hours. The solid product is sublimed in vacuo to give about 140.0 g of product, m.p. 144°-145°.

Workup

  1. temperatureare heated at an internal temperature of 110°-115° for approximately 4 hours

Sources & evidence

ORD record
ord-fcf980d6119143ada01c1551fabc8388
Source dataset
uspto-grants-1977_05
Patent number
US04022897

Reaction notes

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