Methyl Isocyanate → HCID 21434527, compound

HRID 2398050Notes

Reaction equation

HRID 2398050 reaction equation
[Cl:1][C:2]1[N:7]=[C:6]([NH:8][CH2:9][CH2:10][CH2:11][O:12][CH3:13])[N:5]=[C:4]([NH:14][CH2:15][CH2:16][OH:17])[N:3]=1.[CH3:18][N:19]=[C:20]=[O:21]>C(N(CC)CC)C.CN(C)C=O>[Cl:1][C:2]1[N:7]=[C:6]([NH:8][CH2:9][CH2:10][CH2:11][O:12][CH3:13])[N:5]=[C:4]([NH:14][CH2:15][CH2:16][O:17][C:20](=[O:21])[NH:19][CH3:18])[N:3]=1

Participants

5

Reactant 2

HCID 12228Methyl IsocyanateHCID 21434524HCID 21434524, compound

Product 1

HCID 21434527HCID 21434527, compound

Reagents, catalysts & solvents 2

HCID 8471TriethylamineCatalystHCID 6228DimethylformamideSolvent

Procedure

A solution of 5 g 2-chloro-4-(3-methoxypropylamino)-6-(2-hydroxyethylamino)-s-triazine, 1.2 g methyl isocyanate and 10 drops triethylamine in 20 ml dimethylformamide was heated at 100° C. for 2 hours. The dimethylformamide was removed by distillation and the resulting residue was slurried with ether and filtered to give the product as a white powder. The melting point and elemental analysis on the product are tabulated in Table I.

Workup

  1. customThe dimethylformamide was removed by distillation
  2. filtrationfiltered

Sources & evidence

ORD record
ord-31c27c81d6994aafb9e7f7d4c7e88118
Source dataset
uspto-grants-1977_05
Patent number
US04024141

Reaction notes

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