反应详情

A mixture of 2.04 grams (0.01 mole) of 4-benzamidopiperidine, 1.25 grams (1 equivalent) of 2-bromoethanol and 2.76 grams (4-equivalents) of potassium carbonate were stirred at 100° C in 2 milliliters of methyl ethyl ketone for two hours. The mixture was filtered hot and the inorganic residue was washed well with hot methyl ethyl ketone. The filtrate was evaporated to dryness and the resulting white solid recrystallised from ethyl acetate to give 1.55 grams (62%) of 1-(2-hydroxyethyl)-4-benzamidopiperidine.

1. filtrationThe mixture was filtered hot
2. washthe inorganic residue was washed well with hot methyl ethyl ketone
3. customThe filtrate was evaporated to dryness
4. customthe resulting white solid recrystallised from ethyl acetate