Phosphorus oxychloride → HCID 68119874, compound

HRID 2398568Notes

Reaction equation

HRID 2398568 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([CH3:8])=[C:4]([NH:9][C:10](=[O:23])[C:11]2[C:12](=[CH:16][C:17]([C:20](=O)[NH2:21])=[CH:18][CH:19]=2)[C:13](N)=[O:14])[CH:3]=1.P(Cl)(Cl)(Cl)=O>O1CCOCC1>[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([CH3:8])=[C:4]([N:9]2[C:13](=[O:14])[C:12]3=[CH:16][C:17]([C:20]#[N:21])=[CH:18][CH:19]=[C:11]3[C:10]2=[O:23])[CH:3]=1

Participants

4

Reactant 2

HCID 24813Phosphorus oxychlorideHCID 68118832HCID 68118832, compound

Product 1

HCID 68119874HCID 68119874, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

The mixture of 0.3 g of N-(4-amino-o-tolyl)-4-carbamoylphthalamide, 2 ml of dioxane and 5 ml of phosphorus oxychloride is refluxed for 1 hour and evaporated. The residue is taken up in methylene chloride, the solution washed with cold aqueous sodium carbonate, dryed and evaporated, to yield the N-(4-amino-o-tolyl)-4-cyanophthalimide, which is identical with that obtained according to Example 20.

Workup

  1. temperatureis refluxed for 1 hour
  2. customevaporated
  3. washthe solution washed with cold aqueous sodium carbonate
  4. customevaporated

Sources & evidence

ORD record
ord-0c5cf2e055004876afa1c0373777ecc5
Source dataset
uspto-grants-1977_05
Patent number
US04025505

Reaction notes

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