Potassium Carbonate → HCID 12785130, compound

HRID 2398643Notes

Reaction equation

HRID 2398643 reaction equation
Br[C:2]1[S:3][CH:4]=[CH:5][N:6]=1.[SH:7][C:8]1[CH:13]=[CH:12][C:11]([CH:14]([CH3:20])[C:15]([O:17]CC)=[O:16])=[CH:10][CH:9]=1.C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O>[S:3]1[CH:4]=[CH:5][N:6]=[C:2]1[S:7][C:8]1[CH:9]=[CH:10][C:11]([CH:14]([CH3:20])[C:15]([OH:17])=[O:16])=[CH:12][CH:13]=1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 764302-BromothiazoleHCID 20364730HCID 20364730, compound

Product 1

HCID 12785130HCID 12785130, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
85 °C

Procedure

A mixture of 2-bromothiazole (3.9 g) and ethyl 2-(4-mercaptophenyl)propionate (4.56 g), potassium carbonate powder (4.9 g) and dimethylformamide (50 ml) is stirred at 85° C. overnight. The reaction mixture is treated in the same manner as in Example 6 to give 2-[4-(2-thiazolylthio)phenyl]propionic acid melting at 85°-87° C.

Workup

  1. additionThe reaction mixture is treated in the same manner as in Example 6

Sources & evidence

ORD record
ord-a9516701ffd94033b5a7ec387f8339ee
Source dataset
uspto-grants-1977_05
Patent number
US04025528

Reaction notes

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