Hydrochloric Acid → HCID 86734770, compound

HRID 2398647Notes

Reaction equation

HRID 2398647 reaction equation
[CH:1]12[CH2:11][CH:6]3[CH2:7][CH:8]([CH2:10][CH:3]([N:4]([CH2:12][CH2:13][C:14]([C:27]4[O:31][C:30]([C:32]([O:34][CH2:35][CH3:36])=[O:33])=[N:29][N:28]=4)([C:21]4[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=4)[C:15]4[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=4)[CH2:5]3)[CH2:2]1)[CH2:9]2.C(OCC)C.[ClH:42]>CC(O)C>[ClH:42].[CH:1]12[CH2:11][CH:6]3[CH2:7][CH:8]([CH2:10][CH:3]([N:4]([CH2:12][CH2:13][C:14]([C:27]4[O:31][C:30]([C:32]([O:34][CH2:35][CH3:36])=[O:33])=[N:29][N:28]=4)([C:15]4[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=4)[C:21]4[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=4)[CH2:5]3)[CH2:2]1)[CH2:9]2

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 53737089HCID 53737089, compound

Product 1

HCID 86734770HCID 86734770, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

A solution of 10 parts of ethyl 5-{3-[4-azatricyclo(4.3.1.13,8)undecan-4-yl]-1,1-diphenylpropyl}-1,3,4-oxadiazole-2-carboxylate in a minimal amount of diethyl ether is acidified with a solution of hydrogen chloride in 2-propanol. The precipitate which forms is filtered off and recrystallized from a mixture of ethanol and ether to give ethyl 5-{3-[4-azatricyclo(4.3.1.13,8)-undecan-4-yl]-1,1-diphenylpropyl}-1,3,4-oxadiazole-2-carboxylate hydrochloride as yellow-green crystals melting at approximately 199°-200°.

Workup

  1. filtrationThe precipitate which forms is filtered off
  2. customrecrystallized from a mixture of ethanol and ether

Sources & evidence

ORD record
ord-e1297450e2884c01be8f100bfdc89438
Source dataset
uspto-grants-1977_05
Patent number
US04025524

Reaction notes

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