Hydrochloric Acid → HCID 66680818, compound

HRID 239872Notes

Reaction equation

HRID 239872 reaction equation
C[O:2][C:3](=[O:21])[CH2:4][C:5]1[CH:10]=[CH:9][C:8]([C:11]2[CH:19]=[CH:18][CH:17]=[C:16]3[C:12]=2[C:13]([NH2:20])=[N:14][NH:15]3)=[CH:7][CH:6]=1.Cl>CO>[NH2:20][C:13]1[C:12]2[C:16](=[CH:17][CH:18]=[CH:19][C:11]=2[C:8]2[CH:9]=[CH:10][C:5]([CH2:4][C:3]([OH:21])=[O:2])=[CH:6][CH:7]=2)[NH:15][N:14]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 11219755HCID 11219755, compound

Product 1

HCID 66680818HCID 66680818, compoundYield 81.2%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of Example 53A (140 mg) in 1:1 methanol/10% NaOH (1 mL) was stirred at room temperature for 2 hours and adjusted to pH 3 with 10% HCl. The resulting precipitate was collected by filtration to provide 108 mg of the desired product. MS (ESI(+)) m/e 268 (M+H)+.

Workup

  1. filtrationThe resulting precipitate was collected by filtration

Sources & evidence

ORD record
ord-0187ebcc30c94d7da35c30b236720340
Source dataset
uspto-grants-2014_02
Patent number
US08642776B2

Reaction notes

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