反应详情

A suspension of 2-(p-chlorophenyl)-5-benzoxazolylacetic acid (26 g.) and p-toluene sulphonic acid (4.6 g.) in dry benzene (156 ml.) and dry absolute ethanol (78 ml.) was refluxed for 38 hours. Evaporation gave a solid which was dissolved in ethyl acetate (2 l) and washed with an aqueous saturated sodium bicarbonate solution (6 × 50 ml.). Evaporation of the organic phase gave ethyl 2-(2-p-chlorophenyl-5-benzoxazolyl)acetate as a solid (24.1 g.); m.pt. 133° C.

1. dry with materialdry absolute ethanol (78 ml.)
2. temperaturewas refluxed for 38 hours
3. customEvaporation
4. customgave a solid which
5. washwashed with an aqueous saturated sodium bicarbonate solution (6 × 50 ml.)
6. customEvaporation of the organic phase