反应详情

4-chlorophenylisocyanate (3.1 g.) was slowly added to a stirred solution of 2-(3-amino-4-hydroxyphenyl propionitrile (3.3 g.) in xylene (35 ml.) at room temperature. When the addition was complete p-toluenesulphonic acid (250 mg.) was added, and the solution was heated under reflux using a Dean and Stark apparatus. On cooling, the solution was washed with aqueous sodium bicarbonate solution and evaporated to dryness. The residue was recrystallised to give 2-[2-(4-chloroanilino)-5-benzoxazolyl]propionitrile as a creme solid which was characterised by n.m.r. spectroscopy.

1. additionWhen the addition
2. additionwas added
3. temperaturethe solution was heated
4. temperatureunder reflux
5. temperatureOn cooling
6. washthe solution was washed with aqueous sodium bicarbonate solution
7. customevaporated to dryness
8. customThe residue was recrystallised