反应详情

30.0 g. (0.13 mole) of Methyl γ-iodobutyrate (F.F. Blicke, W. B. Wright and M. F. Zienty, J. Amer. Chem. Soc. 63, 2488 (1941) was combined with 36 g. of pyrrolidine (Aldrich) in 300 ml. of benzene, heated at 60° for 0.5 hours and stirred at room temperature for 16 hours. A dark orange layer formed. The benzene solution was decanted, concentrated and distilled (b.p. 100° at 15 mm Hg) to give 10 g. of colorless liquid. The infrared and nmr spectra indicated the product to be methyl γ-pyrrolidinobutyrate. This material was dissolved in 100 ml. of 18% hydrochloric acid and heated at reflux for 28 hours. The solution was concentrated under reduced pressure to give a semi-solid which was triturated with acetone and filtered. Recrystallization from acetic acid/acetone gave 8.3 g. (33%) of the desired acid hydrochloride as colorless crystals, m.p. 126°-127° . The infrared and nmr spectra are consistent with the proposed structure.

1. customA dark orange layer formed
2. customThe benzene solution was decanted
3. concentrationconcentrated
4. distillationdistilled (b.p. 100° at 15 mm Hg)
5. customto give 10 g
6. dissolutionThis material was dissolved in 100 ml
7. temperatureat reflux for 28 hours
8. concentrationThe solution was concentrated under reduced pressure
9. customto give a semi-solid which
10. customwas triturated with acetone
11. filtrationfiltered
12. customRecrystallization from acetic acid/acetone
13. customgave 8.3 g