反应详情

4.68 gm of 6-(4'-amino-3'-nitro-phenyl)-4,5-dihydro-3(2H)-pyridazinone werehydrogenated in 500 ml of ethanol at 40° C. for 4 hours in the presence of 1 gm of platinum dioxide at 5 atmospheres. Thereafter, the solution was cooled and filtered, and the filter cake was boiled with a mixture of 4 parts of isopropanol and 1 part of water. The resulting mixture was filtered, and upon cooling, the desired product crystallized out of the filtrate; m.p. 226° C.

1. temperatureThereafter, the solution was cooled
2. filtrationfiltered
3. additionthe filter cake was boiled with a mixture of 4 parts of isopropanol and 1 part of water
4. filtrationThe resulting mixture was filtered
5. temperatureupon cooling
6. customthe desired product crystallized out of the filtrate