Benzoyl isothiocyanate → N-benzoyl-N'-[2-(2-pyridylmethylthio)ethyl]thiourea

HRID 2399124Notes

Reaction equation

HRID 2399124 reaction equation
[NH2:1][CH2:2][CH2:3][S:4][CH2:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][N:7]=1.[C:12]([N:20]=[C:21]=[S:22])(=[O:19])[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>C(Cl)(Cl)Cl>[C:12]([NH:20][C:21]([NH:1][CH2:2][CH2:3][S:4][CH2:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][N:7]=1)=[S:22])(=[O:19])[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1

Participants

4

Reactant 2

HCID 68284Benzoyl isothiocyanateHCID 128894012-((2-Aminoethyl)thiomethyl)pyridine

Product 1

HCID 21432770N-benzoyl-N'-[2-(2-pyridylmethylthio)ethyl]thiourea

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

A solution of 2-[(2-aminoethyl)thiomethyl]pyridine (6.0 g.) and benzoyl isothiocyanate (6.0 g.) in chloroform (150 ml.) is heated under reflux for one hour and concentrated to give N-benzoyl-N'-[2-(2-pyridylmethylthio)ethyl]thiourea.

Workup

  1. temperatureunder reflux for one hour
  2. concentrationconcentrated

Sources & evidence

ORD record
ord-9c902716b6544b7cb1f56d26aadafa88
Source dataset
uspto-grants-1977_05
Patent number
US04027026

Reaction notes

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