反应详情

A suspension of 2-butylimidazol-5-aldehyde (16.9 g, 0.111 mol), chloromethyl pivalate (21.77 g, 0.145 mol), and potassium carbonate (20.07 g, 0.145) in 200 ml of dimethylformamide was stirred at ambient temperature under argon for four days. The solids were removed by filteration and washed with ether. The combined filtrates were partitioned between diethyl ether and water. The ether phase was washed successively with water and brine, dried over magnesium sulfate and concentrated under vaccum to give 23.6 g of 2-n-butyl-1-pivalyloxymethylimidazol-5-carboxaldehyde.

1. customThe solids were removed by filteration
2. washwashed with ether
3. customThe combined filtrates were partitioned between diethyl ether and water
4. washThe ether phase was washed successively with water and brine
5. dry with materialdried over magnesium sulfate
6. concentrationconcentrated under vaccum