Hydrochloric Acid → HCID 67619063, compound

HRID 2399548Notes

Reaction equation

HRID 2399548 reaction equation
C(OC([NH:8][C@H:9]1[C@@H:13]([CH3:14])[CH2:12][N:11]([C:15]([C:17]2[C:25]3[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=3)[N:19]([CH3:26])[N:18]=2)=[O:16])[CH2:10]1)=O)(C)(C)C.[ClH:27]>C(O)C>[ClH:27].[NH2:8][C@H:9]1[C@@H:13]([CH3:14])[CH2:12][N:11]([C:15]([C:17]2[C:25]3[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=3)[N:19]([CH3:26])[N:18]=2)=[O:16])[CH2:10]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 15291420HCID 15291420, compound

Product 1

HCID 67619063HCID 67619063, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

To a suspension of 2.20 g (6.14 mmol) of cis-3-t-butoxycarbonylamino-4-methyl-1-(1-methylindazol-3-ylcarbonyl)pyrrolidine in 22 ml of ethanol was added 11 ml of ethanol saturated with hydrogen chloride at room temperature, and then the mixture was stirred for 3 hours at room temperature. After completion of the reaction, solvent was distilled off and resultant residue was crystallized with addition of dioxane to give 1.81 g (quantitative) of aimed compound. m.p. 177°-180° C.

Workup

  1. customAfter completion of the reaction, solvent
  2. distillationwas distilled off
  3. customresultant residue was crystallized with addition of dioxane

Sources & evidence

ORD record
ord-f2e24e13573e46b6971c35211b7cbd5e
Source dataset
uspto-grants-1995_09
Patent number
US05449787

Reaction notes

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