Trityl chloride → HCID 19384400, compound

HRID 2399741Notes

Reaction equation

HRID 2399741 reaction equation
[NH2:1][C:2]1([CH2:7][OH:8])[CH2:6][CH2:5][CH2:4][CH2:3]1.[C:9]1([C:15](Cl)([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1>C(Cl)Cl>[OH:8][CH2:7][C:2]1([NH:1][C:15]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)([C:22]2[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=2)[C:16]2[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=2)[CH2:6][CH2:5][CH2:4][CH2:3]1

Participants

4

Reactant 2

HCID 6456Trityl chlorideHCID 663071-Aminocyclopentanemethanol

Product 1

HCID 19384400HCID 19384400, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A mixture of 1-amino-1-cyclopentanemethanol (3.00 g; 26.05 mmol) and triphenylmethylchloride (7.26 g; 26.05 mmol) in 70 ml CH2Cl2 is heated overnight. The reaction mixture is cooled and flash chromatographed twice using 5:1; hexane:EtOAc to obtain 1-hydroxymethyl-1-triphenylmethylaminocyclopentane as a thick yellow oil which is used directly in the next step.

Workup

  1. temperatureis heated overnight
  2. temperatureThe reaction mixture is cooled
  3. customflash chromatographed twice

Sources & evidence

ORD record
ord-cd87fbc3700947f98178f282e5f01614
Source dataset
uspto-grants-1995_09
Patent number
US05451596

Reaction notes

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