Hydrochloric Acid → HCID 19384416, compound

HRID 2399743Notes

Reaction equation

HRID 2399743 reaction equation
C1(C([NH:20][C:21]2([CH2:26][O:27][CH2:28][C:29]3[CH:34]=[CH:33][C:32]([C:35]4[O:36][C:37]5[CH:43]=[CH:42][CH:41]=[CH:40][C:38]=5[N:39]=4)=[CH:31][CH:30]=3)[CH2:25][CH2:24][CH2:23][CH2:22]2)(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.[ClH:44]>C(O)C.C(Cl)Cl>[ClH:44].[NH2:20][C:21]1([CH2:26][O:27][CH2:28][C:29]2[CH:34]=[CH:33][C:32]([C:35]3[O:36][C:37]4[CH:43]=[CH:42][CH:41]=[CH:40][C:38]=4[N:39]=3)=[CH:31][CH:30]=2)[CH2:22][CH2:23][CH2:24][CH2:25]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 19384420HCID 19384420, compound2×

Product 1

HCID 19384416HCID 19384416, compound

Reagents, catalysts & solvents 1

HCID 21584144Dichloromethane ethanolSolvent

Procedure

To a solution of 1-triphenylmethylamino-(4-[benzoxazol-2-yl]benzyloxymethyl)cyclopentane (1.24 g; 2.20 mmol) of 1-triphenylmethylamino-(4-[benzoxazol -2-yl]benzyloxymethyl)cyclopentane in ethanol/CH2Cl2 is added ethanolic HCl until ph≅2. This is then stirred for 72 hrs., concentrated to about one-half the volume and the white precipitate which forms is filtered to obtain 1-amino-[4-(benzoxazol-2-yl)benzyloxymethyl]cyclopentane hydrochloride (m.p. >250° C.).

Workup

  1. concentration, concentrated to about one-half the volume
  2. filtrationthe white precipitate which forms is filtered

Sources & evidence

ORD record
ord-85b404c8d3964ee8828241562fa0836e
Source dataset
uspto-grants-1995_09
Patent number
US05451596

Reaction notes

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