Ammonium Hydroxide → trans-2-Amino-cycloheptanol

HRID 2399747Notes

Reaction equation

HRID 2399747 reaction equation
[CH:1]12[O:8][CH:2]1[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7]2.[OH-].[NH4+:10]>CO>[NH2:10][C@@H:1]1[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][C@H:2]1[OH:8]

Participants

4

Reactant 2

HCID 14923Ammonium HydroxideHCID 675128-Oxabicyclo(5.1.0)octane

Product 1

HCID 12886914trans-2-Amino-cycloheptanol

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

In a sealed tube, cycloheptene oxide (5.44 g; 48.50 mmol)and ammonium hydroxide solution (10 ml) in 4 ml methanol is heated to 80° C. for 72 hrs. After removal of the heat, the mixture is concentrated in vacuo to obtain trans-2-aminocycloheptanol which is used directly in the next step.

Workup

  1. customAfter removal of the heat
  2. concentrationthe mixture is concentrated in vacuo

Sources & evidence

ORD record
ord-5560e5cdb8df4130a5dcb78d0f7550b2
Source dataset
uspto-grants-1995_09
Patent number
US05451596

Reaction notes

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