1-Bromooctane → HCID 67784940, compound

HRID 2399786Notes

Reaction equation

[CH2:1]([O:3][C:4]([C:6]1[CH:7]=[CH:8][C:9]2[C:13]3[CH2:14][CH2:15][CH2:16][C:17]([CH3:19])([CH3:18])[C:12]=3[NH:11][C:10]=2[CH:20]=1)=[O:5])[CH3:2].Br[CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH3:29]>>[CH2:1]([O:3][C:4]([C:6]1[CH:7]=[CH:8][C:9]2[C:13]3[CH:14]([CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH3:29])[CH2:15][CH2:16][C:17]([CH3:19])([CH3:18])[C:12]=3[NH:11][C:10]=2[CH:20]=1)=[O:5])[CH3:2]

Participants

Reactant 2

HCID 81401-Bromooctane

HCID 54447109HCID 54447109, compound

Product 1

HCID 67784940HCID 67784940, compoundYield 103.2%

Procedure

Using the procedure of Example 9, 4.8 g of the ethyl ester from Example 6 was alkylated with 4.38 g of 1-bromooctane to provide 5,6,7,8-tetrahydro-6,6-dimethyl-9-octyl-9H-dibenzo[b,d]pyrrole-3-carboxylic acid ethyl ester (7.0 g;100%) as a yellow oil after purification on a small pad of silica gel.

Sources & evidence

ORD record: ord-4e30327fb8874565b427f1270fcef857
Source dataset: uspto-grants-1995_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05451600

Reaction notes

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