Hydrochloric Acid → HCID 67809084, compound

HRID 2400000Notes

Reaction equation

HRID 2400000 reaction equation
[Cl:1][C@H:2]1[C@@H:10]2[C@@H:6]([CH2:7][N:8](C(Cl)=O)[CH2:9]2)[C:5]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH2:4][CH2:3]1.Cl>O1CCCC1>[ClH:1].[Cl:1][C@H:2]1[C@@H:10]2[C@@H:6]([CH2:7][NH:8][CH2:9]2)[C:5]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[CH2:4][CH2:3]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 54196055HCID 54196055, compound

Product 1

HCID 67809084HCID 67809084, compoundYield 188.1%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A solution of 0.4 g of (3aR,7R,7aR)-7-chloro-2-chlorocarbonyl-4,4-diphenylperhydroisoindole in 6 cm3 of a 1N aqueous solution of hydrochloric acid and 14 cm3 of tetrahydrofuran is heated at 80° C. for 9 hours, with stirring. The reaction mixture is concentrated to dryness under reduced pressure (2.7 kPa). 0.35 g of (3aR,7R,7aR)-7-chloro-4,4-diphenylperhydroisoindole hydrochloride is obtained in the form of a white solid.

Workup

  1. concentrationThe reaction mixture is concentrated to dryness under reduced pressure (2.7 kPa)

Sources & evidence

ORD record
ord-5f1052a761fb414d83a00b319c39bbd3
Source dataset
uspto-grants-1995_09
Patent number
US05451601

Reaction notes

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