Methylamine → HCID 14578461, compound

HRID 2400066Notes

Reaction equation

HRID 2400066 reaction equation
[O:1]1[C:3]2([CH2:8][CH2:7][CH2:6][N:5]([C:9]([O:11][CH3:12])=[O:10])[CH2:4]2)[CH2:2]1.[CH3:13][NH2:14]>>[OH:1][C:3]1([CH2:2][NH:14][CH3:13])[CH2:8][CH2:7][CH2:6][N:5]([C:9]([O:11][CH3:12])=[O:10])[CH2:4]1

Participants

3

Reactant 2

HCID 6329MethylamineHCID 19382148HCID 19382148, compound

Product 1

HCID 14578461HCID 14578461, compound

Procedure

9.3 g (54.3 mmol) of methyl 5-aza-1-oxaspiro[2,5]octane-5-carboxylate are added dropwise to 50 ml of methylamine solution (25% in water) and the mixture is stirred overnight at room temperature. It is then concentrated and the residue is distilled.

Workup

  1. concentrationIt is then concentrated
  2. distillationthe residue is distilled

Sources & evidence

ORD record
ord-37e0c194a5d3413dab5222676e0da90e
Source dataset
uspto-grants-1995_09
Patent number
US05453422

Reaction notes

Loading…