反应详情

5.2 g (28 mmol) of ethyl 6-aza-1-oxaspiro[2,5]-octane-6-carboxylate are added dropwise to 30 ml of methylamine solution (25% in water) and the mixture is stirred overnight at room temperature. It is then concentrated and recrystallized from petroleum ether (hygroscopic crystals).

1. concentrationIt is then concentrated
2. customrecrystallized from petroleum ether (hygroscopic crystals)