Methylamine → HCID 19382193, compound

HRID 2400072Notes

Reaction equation

HRID 2400072 reaction equation
[O:1]1[C:3]2([CH2:8][CH2:7][N:6]([C:9]([O:11][CH2:12][CH3:13])=[O:10])[CH2:5][CH2:4]2)[CH2:2]1.[CH3:14][NH2:15]>>[OH:1][C:3]1([CH2:2][NH:15][CH3:14])[CH2:8][CH2:7][N:6]([C:9]([O:11][CH2:12][CH3:13])=[O:10])[CH2:5][CH2:4]1

Participants

3

Reactant 2

HCID 6329MethylamineHCID 13672926Ethyl 1-oxa-6-azaspiro[2,5]octane-6-carboxylate

Product 1

HCID 19382193HCID 19382193, compound

Procedure

5.2 g (28 mmol) of ethyl 6-aza-1-oxaspiro[2,5]-octane-6-carboxylate are added dropwise to 30 ml of methylamine solution (25% in water) and the mixture is stirred overnight at room temperature. It is then concentrated and recrystallized from petroleum ether (hygroscopic crystals).

Workup

  1. concentrationIt is then concentrated
  2. customrecrystallized from petroleum ether (hygroscopic crystals)

Sources & evidence

ORD record
ord-fac9ac652b8749cf9bf84992d7ccf1be
Source dataset
uspto-grants-1995_09
Patent number
US05453422

Reaction notes

Loading…