Hydrochloric Acid → 4-((Dimethylamino)methyl)-4-piperidinol dihydrochloride

HRID 2400075Notes

Reaction equation

HRID 2400075 reaction equation
[CH3:1][N:2]([CH2:4][C:5]1([OH:16])[CH2:10][CH2:9][N:8](C(OCC)=O)[CH2:7][CH2:6]1)[CH3:3].[ClH:17]>>[ClH:17].[ClH:17].[CH3:3][N:2]([CH2:4][C:5]1([OH:16])[CH2:6][CH2:7][NH:8][CH2:9][CH2:10]1)[CH3:1]

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 19382159HCID 19382159, compound

Product 1

HCID 193822164-((Dimethylamino)methyl)-4-piperidinol dihydrochloride

Procedure

4.5 g (19.4 mmol) of ethyl 4-dimethylaminomethyl-4-hydroxypiperidine-1-carboxylate are heated overnight under reflux with 35 ml of concentrated hydrochloric acid. The product is concentrated, and the crystals are triturated with acetone, filtered off with suction and dried in a vacuum desiccator over P4O10.

Workup

  1. concentrationThe product is concentrated
  2. customthe crystals are triturated with acetone
  3. filtrationfiltered off with suction
  4. dry with materialdried in a vacuum desiccator over P4O10

Sources & evidence

ORD record
ord-706161d1ccac428bbbe9cfaae2ef2e21
Source dataset
uspto-grants-1995_09
Patent number
US05453422

Reaction notes

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