Tetrahydrofuran → HCID 10130365, compound

HRID 2400149Notes

Reaction equation

HRID 2400149 reaction equation
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH:3]=[N:2]1.Cl.[Cl:11][C:12]([NH2:14])=[NH:13].C1COCC1>C1C=CC=CC=1>[ClH:11].[N:1]1[N:2]([C:12]([NH2:14])=[NH:13])[CH:3]=[C:4]2[C:9]=1[CH:8]=[CH:7][CH:6]=[CH:5]2

Participants

5

Reactant 3

HCID 8028TetrahydrofuranHCID 92211H-IndazoleHCID 3084509Chloroformamidinium chloride

Product 1

HCID 10130365HCID 10130365, compoundYield 52.8%

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

940 mg of indazole and 920 mg of chloroformamidine hydrochloride were heated under reflux in 30 ml of benzene of THF for 5 hours, and the crystals formed were removed by filtration. These were recrystallized from ethanol ether to obtain 826 mg of 2H-indazole-2-carboxamidine hydrochloride.

Workup

  1. customthe crystals formed
  2. customwere removed by filtration
  3. customThese were recrystallized from ethanol ether

Sources & evidence

ORD record
ord-f5e371b5f6f84d5fa3d0c063e1752870
Source dataset
uspto-grants-1995_09
Patent number
US05453514

Reaction notes

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