HRID240020
反应详情
EQUATION
反应方程式
REACTANTS
反应物
HCID81531
Diisopropylethylamine
C8H19N
HCID694463
6-bromo-2-oxo-2H-chromene-3-carboxylic acid
C10H5BrO4
HCID697021
3-Imidazo[1,2-a]pyridin-2-yl-phenylamine
C13H11N3
HCID9886157
Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)
C10H15F6N6OP
PRODUCTS
生成物
AUXILIARIES
试剂、催化剂与溶剂
PROCEDURE
实验过程
DIEA (35.6 μL, 0.2 mmol) was added to 6-bromo-3-carboxy-coumarin (50.0 mg, 0.19 mmol) and HATU (77.7 mg, 0.2 mmol) in 2 mL of DMF with constant stirring at room temperature until a clear solution resulted. Subsequently, 3-Imidazo[1,2-a]pyridin-2-yl-phenylamine (38.9 mg, 0.19 mmol) was added and allowed to react overnight when a solid precipitated out of solution. The resulting precipitate was filtered, dried under suction, and finally dried overnight in vacuo to give 61.4 mg of product in 68% yield: LCMS (ESI) m/z 461 (MH+).
WORKUP
后处理
- customresulted
- customto react overnight when a solid
- customprecipitated out of solution
- filtrationThe resulting precipitate was filtered
- customdried under suction, and finally dried overnight in vacuo