反应详情

DIEA (46.0 μL, 0.26 mmol) was added to 8-fluoro-3-carboxy-coumarin (50.3 mg, 0.24 mmol) and HATU (100.5 mg, 0.26 mmol) in 2 mL of DMF with constant stirring at room temperature until a clear solution resulted. Subsequently, 3-Imidazo[1,2-a]pyridin-2-yl-phenylamine (50.0 mg, 0.24 mmol) was added and allowed to react overnight when a solid precipitated out of solution. The resulting precipitate was filtered, dried under suction, and finally dried overnight in vacuo for final product: LCMS (ESI) m/z 400 (MH+).

1. customresulted
2. customto react overnight when a solid
3. customprecipitated out of solution
4. filtrationThe resulting precipitate was filtered
5. dry with materialdried under suction, and finally dried overnight in vacuo for final product