反应详情

(S)-2-[12-(4-tert-Butoxycarbonylphenyl) dodecanoylamino]pentanedioic acid 1-tert-butyl ester (158 mg, 0.28 mmol) was dissolved in THF (6 ml). DIEA (48 μl, 0.28 mmol) was added, and the solution was placed in an ice bath. HSTU (101 mg, 0.28 mmol) was added, and the solution was stirred for 16 h, warming to rt slowly. The solvent was removed under vacuum, and the residue was partitioned between AcOEt (25 ml) and 5% AcOH (15 ml). The organic phase was washed with 5% AcOH (2×15 ml), and saturated NaHCO3, dried, and concentrated under vacuum to yield an oil (0.16 g).

1. customthe solution was placed in an ice bath
2. customThe solvent was removed under vacuum
3. customthe residue was partitioned between AcOEt (25 ml) and 5% AcOH (15 ml)
4. washThe organic phase was washed with 5% AcOH (2×15 ml), and saturated NaHCO3
5. customdried
6. concentrationconcentrated under vacuum