Triphenylphosphine → HCID 86629717, compound

HRID 2400314Notes

Reaction equation

HRID 2400314 reaction equation
[C:1]([O:5][C:6]([C:8]1[S:9][C:10]([CH2:13][Br:14])=[CH:11][CH:12]=1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[C:15]1([P:21]([C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)[C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1>C1(C)C=CC=CC=1>[Br-:14].[C:1]([O:5][C:6]([C:8]1[S:9][C:10]([CH2:13][P+:21]([C:22]2[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=2)([C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)[C:15]2[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=2)=[CH:11][CH:12]=1)=[O:7])([CH3:4])([CH3:3])[CH3:2]

Participants

4

Reactant 2

HCID 11776TriphenylphosphineHCID 57661602HCID 57661602, compound

Product 1

HCID 86629717HCID 86629717, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Conditions

Temperature
70 °C

Procedure

To 5-bromomethylthiophene-2-carboxylic acid tert-butyl ester (14.9 mmol, 43.8 mmol) was added toluene (300 mL) and triphenylphosphine (14.1 g, 53.8 mmol). The mixture was heated to 70° C. overnight. The solvent was remove in vacuo to give (5-tert-Butoxycarbonyl-thiophen-2-ylmethyl)-triphenylphosphonium bromide

Workup

  1. customThe solvent was remove in vacuo

Sources & evidence

ORD record
ord-1e0cb72583014a2597378bafe757e9c8
Source dataset
uspto-grants-2014_08
Patent number
US08796205B2

Reaction notes

Loading…