Cyclopropanecarbonyl chloride → HCID 86762579, compound

HRID 2400911Notes

Reaction equation

[NH2:1][C:2]1([CH2:8][N:9]2[C:13](=[O:14])/[C:12](=[CH:15]/[C:16]3[CH:17]=[C:18]4[C:22](=[CH:23][CH:24]=3)[N:21]([CH2:25][C:26]3[CH:31]=[CH:30][C:29]([C:32]([F:35])([F:34])[F:33])=[CH:28][C:27]=3[C:36]([F:39])([F:38])[F:37])[N:20]=[CH:19]4)/[S:11][C:10]2=[O:40])[CH2:7][CH2:6][O:5][CH2:4][CH2:3]1.[CH:41]1([C:44](Cl)=[O:45])[CH2:43][CH2:42]1>>[F:37][C:36]([F:38])([F:39])[C:27]1[CH:28]=[C:29]([C:32]([F:33])([F:34])[F:35])[CH:30]=[CH:31][C:26]=1[CH2:25][N:21]1[C:22]2[C:18](=[CH:17][C:16](/[CH:15]=[C:12]3/[C:13](=[O:14])[N:9]([CH2:8][C:2]4([NH:1][C:44]([CH:41]5[CH2:43][CH2:42]5)=[O:45])[CH2:3][CH2:4][O:5][CH2:6][CH2:7]4)[C:10](=[O:40])[S:11]/3)=[CH:24][CH:23]=2)[CH:19]=[N:20]1

Participants

Reactant 2

HCID 77637Cyclopropanecarbonyl chloride

HCID 86762580HCID 86762580, compound

Product 1

HCID 86762579HCID 86762579, compound

Procedure

N-(4-{[(5Z)-5-({1-[2,4-Bis(trifluoromethyl)benzyl]-1H-indazol-5-yl}methylidene)-2,4-dioxo-1,3-thiazolidin-3-yl]methyl}tetrahydro-2H-pyran-4-yl)cyclopropane carboxamide was prepared from (5Z)-3-[(4-aminotetrahydro-2H-pyran-4-yl)methyl]-5-({1-[2,4-bis(trifluoromethyl)benzyl]-1H-indazol-5-yl}methylidene)-1,3-thiazolidine-2,4-dione (Example 310) and cyclopropanecarbonyl chloride following General Procedure R3.

Sources & evidence

ORD record: ord-72433ca99e5c4194bc128a4c0e3820f6
Source dataset: uspto-grants-2014_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08796256B2

Reaction notes

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