Diisopropylethylamine → 8-Trifluoromethoxy-2-oxo-2H-chromene-3-carboxylic acid [3-(6-methoxy-naphthalen-2-yl)-phenyl]-amide

HRID 240098Notes

Reaction equation

HRID 240098 reaction equation
CCN(C(C)C)C(C)C.[F:10][C:11]([F:28])([F:27])[O:12][C:13]1[CH:14]=[CH:15][CH:16]=[C:17]2[C:22]=1[O:21][C:20](=[O:23])[C:19]([C:24]([OH:26])=O)=[CH:18]2.CN(C(ON1N=NC2C=CC=NC1=2)=[N+](C)C)C.F[P-](F)(F)(F)(F)F.[CH3:53][O:54][C:55]1[CH:56]=[C:57]2[C:62](=[CH:63][CH:64]=1)[CH:61]=[C:60]([C:65]1[CH:66]=[C:67]([NH2:71])[CH:68]=[CH:69][CH:70]=1)[CH:59]=[CH:58]2>CN(C=O)C>[CH3:53][O:54][C:55]1[CH:56]=[C:57]2[C:62](=[CH:63][CH:64]=1)[CH:61]=[C:60]([C:65]1[CH:66]=[C:67]([NH:71][C:24]([C:19]3[C:20](=[O:23])[O:21][C:22]4[C:17]([CH:18]=3)=[CH:16][CH:15]=[CH:14][C:13]=4[O:12][C:11]([F:10])([F:28])[F:27])=[O:26])[CH:68]=[CH:69][CH:70]=1)[CH:59]=[CH:58]2

Participants

6

Reactant 4

HCID 81531DiisopropylethylamineHCID 9886157Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)HCID 22724074HCID 22724074, compoundHCID 866503588-Trifluoromethoxy-3-carboxy-coumarin

Product 1

HCID 866504028-Trifluoromethoxy-2-oxo-2H-chromene-3-carboxylic acid [3-(6-methoxy-naphthalen-2-yl)-phenyl]-amideYield 49.5%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

DIEA (0.0115 mL, 0.067 mmol) was added to 8-trifluoromethoxy-3-carboxy-coumarin (0.016 g, 0.06 mmol) and HATU (0.025 g, 0.067 mmol) in 0.5 mL of DMF with constant stirring at room temperature until a clear solution resulted. Subsequently, 3-(6-methoxy-naphthalen-2-yl)-phenylamine (0.015 g, 0.06 mmol) was added and allowed to react overnight when a solid precipitated out of solution. The resulting precipitate was filtered, dried under suction, and finally dried overnight in vacuo to give 0.015 g of product in 49% yield: LCMS (ESI) m/z 506 (MH+).

Workup

  1. customresulted
  2. customto react overnight when a solid
  3. customprecipitated out of solution
  4. filtrationThe resulting precipitate was filtered
  5. customdried under suction, and finally dried overnight in vacuo

Sources & evidence

ORD record
ord-27bf1ec1ec3049efba2efec05ef656e7
Source dataset
uspto-grants-2014_02
Patent number
US08642788B2

Reaction notes

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