2-Methylindole → HCID 57586067, compound

HRID 2401076Notes

Reaction equation

HRID 2401076 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[S:8]([NH:11][C:12]1[C:17]([C:18]2[CH:23]=[CH:22][C:21]([CH2:24]Cl)=[CH:20][CH:19]=2)=[N:16][CH:15]=[CH:14][N:13]=1)(=[O:10])=[O:9].[CH3:26][C:27]1[NH:28][C:29]2[C:34]([CH:35]=1)=[CH:33][CH:32]=[CH:31][CH:30]=2>>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[S:8]([NH:11][C:12]1[C:17]([C:18]2[CH:23]=[CH:22][C:21]([CH2:24][N:28]3[C:29]4[C:34](=[CH:33][CH:32]=[CH:31][CH:30]=4)[CH:35]=[C:27]3[CH3:26])=[CH:20][CH:19]=2)=[N:16][CH:15]=[CH:14][N:13]=1)(=[O:10])=[O:9]

Participants

3

Reactant 2

HCID 72242-MethylindoleHCID 574442542-chloro-N-{3-[4-(chloromethyl)phenyl]pyrazin-2-yl}benzenesulfonamide2×

Product 1

HCID 57586067HCID 57586067, compoundYield 81%

Procedure

Following the general method as outlined in Example 1 (Method B), starting from 2-chloro-N-{3-[4-(chloromethyl)phenyl]pyrazin-2-yl}benzenesulfonamide (Intermediate 8), and 2-methyl-1-H-indole, the title compound was isolated as a yellow solid in 81% yield (96% purity by HPLC).

Sources & evidence

ORD record
ord-b3c7a7873c1348129c3c4607aa09fa1a
Source dataset
uspto-grants-2014_08
Patent number
US08796280B2

Reaction notes

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