Hydrochloric Acid → HCID 54591075, compound

HRID 2401133Notes

Reaction equation

HRID 2401133 reaction equation
C(OC([N:8]1[CH2:37][CH2:36][C:11]2([C:16](=[O:17])[N:15]([C:18]3[C:19]([CH3:35])=[N:20][C:21]([N:24]4[CH2:28][CH2:27][C@@H:26]([N:29]5[CH2:33][CH2:32][CH2:31][C@@H:30]5[CH3:34])[CH2:25]4)=[CH:22][CH:23]=3)[CH2:14][CH2:13][CH2:12]2)[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:38]>CO.CCO>[ClH:38].[CH3:35][C:19]1[C:18]([N:15]2[CH2:14][CH2:13][CH2:12][C:11]3([CH2:10][CH2:9][NH:8][CH2:37][CH2:36]3)[C:16]2=[O:17])=[CH:23][CH:22]=[C:21]([N:24]2[CH2:28][CH2:27][C@@H:26]([N:29]3[CH2:33][CH2:32][CH2:31][C@@H:30]3[CH3:34])[CH2:25]2)[N:20]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 54590988HCID 54590988, compound

Product 1

HCID 54591075HCID 54591075, compoundYield 100%

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 887MethanolSolvent

Procedure

To a solution of 2-[2-methyl-6-((2S,3′R)-2-methyl-[1,3′]bipyrrolidinyl-1′-yl)-pyridin-3-yl]-1-oxo-2,9-diaza-spiro[5.5]undecane-9-carboxylic acid tert-butyl ester (20 mg, 0.04 mmol) in methanol (2 mL) was added a saturated solution of HCl in EtOH (2 mL) and stirred the resulting mixture for 20 hours. Concentrated the reaction mixture and dried under high vacuum to afford 20 mg (100% yield) of the title compound as a solid.

Workup

  1. concentrationConcentrated the reaction mixture
  2. customdried under high vacuum

Sources & evidence

ORD record
ord-16177403f3884c42ae83ed4ddd88a6b0
Source dataset
uspto-grants-2014_08
Patent number
US08796278B2

Reaction notes

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