Methyl iodide → Methyl 2-methyl-3-oxopentanoate

Temperature

0 °C

Methyl 3-oxopentanoate (6.27 ml, 50 mmol) in tetrahydrofuran (100 ml) and potassium carbonate (20.73 g, 150 mmol) was heated at reflux under argon for 3 hours, reaction mixture was cooled in an ice bath and and iodomethane (3.75 ml, 60.0 mmol) was added dropwsie. The reaction mixture was stirred at 0° C. for 6 hours, and allowed to warm to room temperature while stirring overnight. The reaction mixture was filtered through a celite and the filtrate was evaporated under reduced pressure to give the title compound as an oil (7.2 g);

1. temperatureat reflux under argon for 3 hours
2. customreaction mixture
3. temperaturewas cooled in an ice bath
4. temperatureto warm to room temperature
5. stirringwhile stirring overnight
6. filtrationThe reaction mixture was filtered through a celite
7. customthe filtrate was evaporated under reduced pressure

ORD record

ord-8b7c606500d1481c89270802f8f8ae1b

Source dataset

uspto-grants-2014_08

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08796283B2