Diisopropylethylamine → 8-Methoxy-2-oxo-2H-chromene-3-carboxylic acid (2'-(Morpholine-4-sulfonyl)-biphenyl-3-yl)-amide

HRID 240125Notes

Reaction equation

HRID 240125 reaction equation
CCN(C(C)C)C(C)C.[CH3:10][O:11][C:12]1[CH:13]=[CH:14][CH:15]=[C:16]2[C:21]=1[O:20][C:19](=[O:22])[C:18]([C:23]([OH:25])=O)=[CH:17]2.CN(C(ON1N=NC2C=CC=NC1=2)=[N+](C)C)C.F[P-](F)(F)(F)(F)F.[N:50]1([S:56]([C:59]2[CH:64]=[CH:63][CH:62]=[CH:61][C:60]=2[C:65]2[CH:70]=[CH:69][CH:68]=[C:67]([NH2:71])[CH:66]=2)(=[O:58])=[O:57])[CH2:55][CH2:54][O:53][CH2:52][CH2:51]1>CN(C=O)C>[N:50]1([S:56]([C:59]2[CH:64]=[CH:63][CH:62]=[CH:61][C:60]=2[C:65]2[CH:70]=[CH:69][CH:68]=[C:67]([NH:71][C:23]([C:18]3[C:19](=[O:22])[O:20][C:21]4[C:16]([CH:17]=3)=[CH:15][CH:14]=[CH:13][C:12]=4[O:11][CH3:10])=[O:25])[CH:66]=2)(=[O:58])=[O:57])[CH2:51][CH2:52][O:53][CH2:54][CH2:55]1

Participants

6

Reactant 4

HCID 81531DiisopropylethylamineHCID 2345628-Methoxy-2-oxo-2H-chromene-3-carboxylic acidHCID 9886157Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)HCID 668647442'-(Morpholine-4-sulfonyl)-biphenyl-3-ylamine

Product 1

HCID 867622778-Methoxy-2-oxo-2H-chromene-3-carboxylic acid (2'-(Morpholine-4-sulfonyl)-biphenyl-3-yl)-amideYield 73.6%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

DIEA (0.009 mL, 0.052 mmol) was added to 8-methoxy-3-carboxy-coumarin (0.010 g, 0.047 mmol) and HATU (0.020 g, 0.052 mmol) in 0.36 mL of DMF with constant stirring at room temperature until a clear solution resulted. Subsequently, 2′-(Morpholine-4-sulfonyl)-biphenyl-3-ylamine (0.015 g, 0.047 mmol) was added and allowed to react overnight when a solid precipitated out of solution. The resulting precipitate was filtered, dried under suction, and finally dried overnight in vacuo to give 0.018 g of product in 73% yield: LCMS (ESI) m/z 521 (MH+).

Workup

  1. customresulted
  2. customto react overnight when a solid
  3. customprecipitated out of solution
  4. filtrationThe resulting precipitate was filtered
  5. customdried under suction, and finally dried overnight in vacuo

Sources & evidence

ORD record
ord-1d4d9e11dda747658e0c1514c463cf0e
Source dataset
uspto-grants-2014_02
Patent number
US08642788B2

Reaction notes

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