反应详情

To a suspension of 2-[(5S)-3-(6-bromopyridin-3-yl)-2-oxo-5-(propan-2-yl)imidazolidin-1-yl]-N-[3-(trifluoromethyl)phenyl]acetamide (50 mg) and tris(2,4-pentanedionato)iron(III) (55 mg) in THF (1 mL) and NMP (0.1 mL) was added n-propylmagnesium bromide (2M solution in THF, 0.31 mL), and the mixture was stirred at room temperature for 1 hr. Saturated aqueous ammonium chloride solution was added thereto, the resulting mixture was extracted with acetic acid, and the organic layer was washed with water and brine. After drying over anhydrous sodium sulfate, the desiccant was filtered off, and the filtrate was concentrated under reduced pressure. The residue was purified by column chromatography (hexane/ethyl acetate) to afford the title compound (24 mg).

1. extractionthe resulting mixture was extracted with acetic acid
2. washthe organic layer was washed with water and brine
3. dry with materialAfter drying over anhydrous sodium sulfate
4. filtrationthe desiccant was filtered off
5. concentrationthe filtrate was concentrated under reduced pressure
6. customThe residue was purified by column chromatography (hexane/ethyl acetate)