反应详情

DIEA (0.0085 mL, 0.049 mmol) was added to 8-methoxy-3-carboxy-coumarin (0.009 g, 0.044 mmol) and HATU (0.019 g, 0.049 mmol) in 0.3 mL of DMF with constant stirring at room temperature until a clear solution resulted. Subsequently, 3-(2-oxo-2,3-dihydro-1H-benzoimidazol-5-yl)-phenylamine (0.009 g, 0.044 mmol) was added and allowed to react overnight when a solid precipitated out of solution. The resulting precipitate was filtered, dried under suction, and finally dried overnight in vacuo to give 0.007 g of product in 39% yield: LCMS (ESI) m/z 428 (MH+).

1. customresulted
2. customto react overnight when a solid
3. customprecipitated out of solution
4. filtrationThe resulting precipitate was filtered
5. customdried under suction, and finally dried overnight in vacuo