Water → HCID 519849, compound

HRID 2402286Notes

Reaction equation

HRID 2402286 reaction equation
[CH3:1][O:2][C:3]1[CH:10]=[CH:9][C:6]([CH2:7][NH2:8])=[CH:5][CH:4]=1.[C:11]1(=O)[O:16][C:14](=[O:15])[C:13]2=[CH:17][CH:18]=[CH:19][CH:20]=[C:12]12.O>C(O)(=O)C>[CH3:1][O:2][C:3]1[CH:10]=[CH:9][C:6]([CH2:7][N:8]2[C:14](=[O:15])[C:13]3[C:12](=[CH:20][CH:19]=[CH:18][CH:17]=3)[C:11]2=[O:16])=[CH:5][CH:4]=1

Participants

5

Reactant 3

HCID 962WaterHCID 6811Phthalic AnhydrideHCID 754524-Methoxybenzylamine

Product 1

HCID 519849HCID 519849, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

4-Methoxybenzylamine (4.9 g, 36 mmol) was added to phthalic anhydride (4.5 g, 30 mmol) in 15 mL glacial acetic acid. The reaction was stirred at 100° C. for 4 h as water was collected with a Dean-Stark trap. Solvent was evaporated and the product was obtained by crystallization from ethanol (7 g, 87%).

Workup

  1. customwas collected with a Dean-Stark trap
  2. customSolvent was evaporated
  3. customthe product was obtained by crystallization from ethanol (7 g, 87%)

Sources & evidence

ORD record
ord-fbb5cd5062ed4b99b9f884e2a485fcc2
Source dataset
uspto-grants-2014_08
Patent number
US08796313B2

Reaction notes

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