Ammonium Hydroxide → 6-aminopyridine-3-sulfonamide

HRID 2402302Notes

Reaction equation

HRID 2402302 reaction equation
Cl[C:2]1[N:7]=[CH:6][C:5]([S:8]([NH2:11])(=[O:10])=[O:9])=[CH:4][CH:3]=1.[NH4+:12].[OH-]>[Cl-].[Na+].O>[NH2:12][C:2]1[N:7]=[CH:6][C:5]([S:8]([NH2:11])(=[O:10])=[O:9])=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 14923Ammonium HydroxideHCID 12015126-chloropyridine-3-sulfonamide

Product 1

HCID 4595346-aminopyridine-3-sulfonamide

Reagents, catalysts & solvents 1

HCID 57417360Sodium chloride; waterSolvent

Conditions

Temperature
110 °C

Procedure

6-Chloropyridine-3-sulfonic acid amide (200 mg, 1 mmol) was placed in a sealed tube with 2 mL 28% aq. NH4OH and heated to 110° C. for 4 h. The mixture was diluted with brine and the title compound was collected as a solid (120 mg, 67%).

Workup

  1. customthe title compound was collected as a solid (120 mg, 67%)

Sources & evidence

ORD record
ord-99ba472de0b444089f6d7083198c06b6
Source dataset
uspto-grants-2014_08
Patent number
US08796313B2

Reaction notes

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