Hydrochloric Acid → HCID 178511697, compound

HRID 2402574Notes

Reaction equation

HRID 2402574 reaction equation
C(OC(=O)N[C@H]1CC[C@@H](O)CC1)(C)(C)C.[Cl:16]C1C2C(=C(Cl)C(F)=CC=2)C=CN=1.Cl.Cl.[NH2:31][C@@H:32]1[CH2:37][CH2:36][C@H:35]([O:38][C:39]2[CH:40]=[C:41]3[C:46](=[CH:47][C:48]=2Cl)[C:45]([OH:50])=[N:44][CH:43]=[CH:42]3)[CH2:34][CH2:33]1>>[NH2:31][C@@H:32]1[CH2:37][CH2:36][C@H:35]([O:38][C:39]2[C:40]([Cl:16])=[C:41]3[C:46](=[CH:47][CH:48]=2)[C:45](=[O:50])[NH:44][CH:43]=[CH:42]3)[CH2:34][CH2:33]1

Participants

5

Reactant 4

HCID 313Hydrochloric AcidHCID 584681281,5-Dichloro-6-fluoroisoquinolineHCID 178418813HCID 178418813, compoundHCID 178479273HCID 178479273, compound

Product 1

HCID 178511697HCID 178511697, compound

Procedure

Starting from cis-(4-hydroxy-cyclohexyl)-carbamic acid tert-butyl ester and 1,5-dichloro-6-fluoro-isoquinoline (9), the title compound was prepared as hydrochloride following the route described for 6-(cis-4-amino-cyclohexyloxy)-7-chloro-isoquinolin-1-ol hydrochloride (10). Rt=1.04 min (Method B). Detected mass: 293.1/295.1 (M+H+).

Sources & evidence

ORD record
ord-ef02469c4b5d4cb48ab014f214d70f1b
Source dataset
uspto-grants-2014_08
Patent number
US08796458B2

Reaction notes

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