Succinic anhydride → HCID 131728227, compound

HRID 2403028Notes

Reaction equation

HRID 2403028 reaction equation
[CH2:1]([N:19]([CH2:87][CH2:88][CH2:89][CH2:90][CH2:91][CH2:92][CH2:93][CH2:94][CH2:95][CH2:96][CH2:97][CH2:98][CH2:99][CH2:100][CH2:101][CH2:102][CH2:103][CH3:104])[C:20]([CH2:22][CH2:23][CH:24]([CH:26]1[C:42]2([CH3:43])[CH:29]([CH:30]3[CH:39]([CH2:40][CH2:41]2)[C:38]2([CH3:44])[CH:33]([CH2:34][CH:35]([O:45][C:46](=[O:86])[NH:47][CH2:48][CH2:49][CH2:50][CH2:51][CH2:52][C:53]([N:55]4[CH2:59][CH:58]([OH:60])[CH2:57][CH:56]4[CH:61]([C:80]4[CH:85]=[CH:84][CH:83]=[CH:82][CH:81]=4)[O:62][CH:63]([C:72]4[CH:77]=[CH:76][C:75]([O:78][CH3:79])=[CH:74][CH:73]=4)[C:64]4[CH:69]=[CH:68][C:67]([O:70][CH3:71])=[CH:66][CH:65]=4)=[O:54])[CH2:36][CH2:37]2)[CH2:32][CH2:31]3)[CH2:28][CH2:27]1)[CH3:25])=[O:21])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH3:18].[C:105]1(=[O:111])[O:110][C:108](=[O:109])[CH2:107][CH2:106]1.C(N(CC)CC)C>CN(C1C=CN=CC=1)C.ClCCl>[CH3:71][O:70][C:67]1[CH:68]=[CH:69][C:64]([CH:63]([C:72]2[CH:77]=[CH:76][C:75]([O:78][CH3:79])=[CH:74][CH:73]=2)[O:62][CH:61]([C:80]2[CH:81]=[CH:82][CH:83]=[CH:84][CH:85]=2)[CH:56]2[N:55]([C:53](=[O:54])[CH2:52][CH2:51][CH2:50][CH2:49][CH2:48][NH:47][C:46]([O:45][CH:35]3[CH2:34][CH:33]4[C:38]([CH3:44])([CH:39]5[CH:30]([CH2:31][CH2:32]4)[CH:29]4[C:42]([CH3:43])([CH:26]([CH:24]([CH3:25])[CH2:23][CH2:22][C:20](=[O:21])[N:19]([CH2:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH3:18])[CH2:87][CH2:88][CH2:89][CH2:90][CH2:91][CH2:92][CH2:93][CH2:94][CH2:95][CH2:96][CH2:97][CH2:98][CH2:99][CH2:100][CH2:101][CH2:102][CH2:103][CH3:104])[CH2:27][CH2:28]4)[CH2:41][CH2:40]5)[CH2:37][CH2:36]3)=[O:86])[CH2:59][CH:58]([O:60][C:105](=[O:111])[CH2:106][CH2:107][C:108]([OH:110])=[O:109])[CH2:57]2)=[CH:65][CH:66]=1

Participants

6

Reactant 3

HCID 7922Succinic anhydrideHCID 8471TriethylamineHCID 131728228HCID 131728228, compound

Product 1

HCID 131728227HCID 131728227, compoundYield 71.5%

Reagents, catalysts & solvents 2

HCID 142844-(Dimethylamino)pyridineCatalystHCID 6344DichloromethaneSolvent

Procedure

Referring to scheme 21, Compound 84 (1.44 g, 1 mmol) was mixed with succinic anhydride (0.15 g, 1.5 mmol) and DMAP (0.0122 g, 0.1 mmol) and dried in a vacuum at 40° C. overnight. The mixture was dissolved in anhydrous dichloromethane (5 mL), triethylamine (0.101 g, 0.14 mL, 1 mmol) was added and the solution was stirred at room temperature under argon atmosphere for 16 h. It was then diluted with dichloromethane (50 mL) and washed with ice cold aqueous citric acid (5% wt., 25 mL) and water (2×25 mL). The organic phase was dried over anhydrous sodium sulfate and concentrated to dryness. The crude product was purified by column chromatography to afford compound 86 as white solid (1.1 g, 71% yield; Rf=0.5 in 10% MeOH/CHCl3).

Workup

  1. customdried in a vacuum at 40° C. overnight
  2. dissolutionThe mixture was dissolved in anhydrous dichloromethane (5 mL)
  3. washwashed with ice cold aqueous citric acid (5% wt., 25 mL) and water (2×25 mL)
  4. dry with materialThe organic phase was dried over anhydrous sodium sulfate
  5. concentrationconcentrated to dryness
  6. customThe crude product was purified by column chromatography

Sources & evidence

ORD record
ord-3a68f24f548c498f808d1e4fa4849483
Source dataset
uspto-grants-2014_08
Patent number
US08796436B2

Reaction notes

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