Tetrahydrofuran → Linoleyl alcohol

A clean, dry 200 L glass reactor fitted with an argon inlet and thermowell was charged with 60 L of THF and 5.73 Kg (20.4 mol) of linoleic acid. The contents of the reactor were cooled below 0° C. using an acetone-dry ice bath. To this cold solution 13.8 L of Vitride (60% wt/vol) in toluene was added slowly maintaining the internal temperature of the reaction mixture below 0° C. (Note: Initial addition of vitride was exothermic and frothing was observed. The frothing ceased after 15 minutes of addition). The addition of vitride took 3 hr and 45 minutes. After completion of the addition, the reaction mixture was stirred at ambient temperature for 2 hr. An aliquot was taken and quenched with sat. Na2SO4 and the thus obtained crude product was analyzed by TLC for the presence of the starting acid. The TLC showed completion of the reaction and the reaction mixture was again cooled below 0° C. in about 45 minutes. A saturated solution of sodium sulfate (prepared by dissolving 1.1 Kg of sodium sulfate in 1.5 L of water) was slowly added to the reaction mixture over 45 min. After completion of the addition, 25 L of ethyl acetate was added over a period of 30 min with stirring. The obtained reaction mixture was filtered through a celite bed over a period of 45 min and the celite bed was washed with an additional 17 L of ethyl acetate to remove all product from the residue. The combined organics were concentrated under reduced pressure. The residue was dissolved in 15 L of ethyl acetate and the organic layer was washed with water (2×7 L) and dried over sodium sulfate (1.1 Kg). After filtration the organic layer was concentrated under reduced pressure and dried under high vacuum to obtain the product linoleyl alcohol as an oil. Crude yield=5.5 Kg (theoretical yield=5.43 Kg). This product was used without further purification in the next step.

1. customA clean, dry 200 L glass reactor
2. customfitted with an argon inlet
3. temperatureThe contents of the reactor were cooled below 0° C.
4. temperaturemaintaining the internal temperature of the reaction mixture below 0° C. (Note
5. additionThe frothing ceased after 15 minutes of addition)
6. additionAfter completion of the addition
7. customquenched with sat. Na2SO4
8. customthe thus obtained crude product
9. customcompletion of the reaction
10. waitthe reaction mixture was again cooled below 0° C. in about 45 minutes
11. additionwas added over a period of 30 min
12. stirringwith stirring
13. customThe obtained reaction mixture
14. filtrationwas filtered through a celite bed over a period of 45 min
15. washthe celite bed was washed with an additional 17 L of ethyl acetate
16. customto remove all product from the residue
17. concentrationThe combined organics were concentrated under reduced pressure
18. dissolutionThe residue was dissolved in 15 L of ethyl acetate
19. washthe organic layer was washed with water (2×7 L)
20. dry with materialdried over sodium sulfate (1.1 Kg)
21. filtrationAfter filtration the organic layer
22. concentrationwas concentrated under reduced pressure
23. customdried under high vacuum

ORD record

ord-bae519e3f5dd4c75aa39137e4ba13780

Source dataset

uspto-grants-2014_08

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08802644B2