Lithium hydroxide, monohydrate → Lithium 1-(4,4-difluorocyclohexyl)azetidine-2-carboxylate

HRID 2403166Notes

Reaction equation

HRID 2403166 reaction equation
[F:1][C:2]1([F:16])[CH2:7][CH2:6][CH:5]([N:8]2[CH2:11][CH2:10][CH:9]2[C:12]([O:14]C)=[O:13])[CH2:4][CH2:3]1.O.[OH-].[Li+:19]>>[F:16][C:2]1([F:1])[CH2:3][CH2:4][CH:5]([N:8]2[CH2:11][CH2:10][CH:9]2[C:12]([O-:14])=[O:13])[CH2:6][CH2:7]1.[Li+:19]

Participants

3

Reactant 2

HCID 168937Lithium hydroxide, monohydrateHCID 86692750Methyl 1-(4,4-difluorocyclohexyl)azetidine-2-carboxylate

Product 1

HCID 86692758Lithium 1-(4,4-difluorocyclohexyl)azetidine-2-carboxylate

Procedure

The reaction of methyl 1-(4,4-difluorocyclohexyl)azetidine-2-carboxylate 19B and lithium hydroxide monohydrate yielded lithium 1-(4,4-difluorocyclohexyl)azetidine-2-carboxylate as a light yellow solid (quant). MS ISP (m/e): 220.2 (100) [(M+H)]+, 200.2 (100) [(M−HF+H)]+.

Sources & evidence

ORD record
ord-4b38f3ee749242ceb40458a645c6b140
Source dataset
uspto-grants-2014_08
Patent number
US08802665B2

Reaction notes

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