Lithium hydroxide, monohydrate → Lithium 1-(1-(ethoxycarbonyl)piperidin-4-yl)azetidine-2-carboxylate
Reaction equation
C[O:2][C:3]([CH:5]1[CH2:8][CH2:7][N:6]1[CH:9]1[CH2:14][CH2:13][N:12]([C:15]([O:17][CH2:18][CH3:19])=[O:16])[CH2:11][CH2:10]1)=[O:4].O.[OH-].[Li+:22]>>[CH2:18]([O:17][C:15]([N:12]1[CH2:11][CH2:10][CH:9]([N:6]2[CH2:7][CH2:8][CH:5]2[C:3]([O-:4])=[O:2])[CH2:14][CH2:13]1)=[O:16])[CH3:19].[Li+:22]Participants
3
Procedure
The reaction of ethyl 4-(2-(methoxycarbonyl)azetidin-1-yl)piperidine-1-carboxylate 19K and lithium hydroxide monohydrate yielded lithium 1-(1-(ethoxycarbonyl)piperidin-4-yl)azetidine-2-carboxylate as light yellow solid (quant.). MS ISP (m/e): 257.1 (100) [(M+H)]+.
Sources & evidence
- ORD record
- ord-73493803dfed4651a55bf3357d170723
- Source dataset
- uspto-grants-2014_08
- Patent number
- US08802665B2
Reaction notes
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