2,2,2-Trifluoroethanol → HCID 79080778, compound

HRID 2403327Notes

Reaction equation

HRID 2403327 reaction equation
[Cl:1][C:2]1[N:7]=[C:6](Cl)[C:5]([F:9])=[CH:4][N:3]=1.[CH2:10]([OH:15])[C:11]([F:14])([F:13])[F:12].C(=O)([O-])[O-].[K+].[K+]>>[Cl:1][C:2]1[N:7]=[C:6]([O:15][CH2:10][C:11]([F:14])([F:13])[F:12])[C:5]([F:9])=[CH:4][N:3]=1

Participants

4

Reactant 3

HCID 64092,2,2-TrifluoroethanolHCID 11430Potassium CarbonateHCID 2507052,4-Dichloro-5-fluoropyrimidine

Product 1

HCID 79080778HCID 79080778, compound

Procedure

2,4-Dichloro-5-fluoropyrimidine (100 mg, CAS 2927-71-1) was combined with trifluoroethanol (1.09 ml) to give a colourless solution. Potassium carbonate (82.8 mg) was added. The reaction mixture was stirred at room temperature for 30 min. TLC at t=30 min showed the reaction was complete. The reaction mixture was filtered through sintered glass and concentrated in vacuo. The residue was triturated with diethyl ether, then filtered through sintered glass and dried in vacuo.

Workup

  1. customto give a colourless solution
  2. customat t=30 min
  3. filtrationThe reaction mixture was filtered through sintered glass
  4. concentrationconcentrated in vacuo
  5. customThe residue was triturated with diethyl ether
  6. filtrationfiltered through sintered glass
  7. customdried in vacuo

Sources & evidence

ORD record
ord-ea8eb32afd3a47eb8839e68a69dfb6b0
Source dataset
uspto-grants-2014_08
Patent number
US08802673B2

Reaction notes

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