反应详情

To a solution of piperazine (1 g) and triethylamine (1.78 mL) in dichloromethane (20 mL) at 0° C. was added dropwise trifluoromethanesulfonyl chloride (1.24 mL). The reaction mixture was stirred at room temperature for 16 h and then quenched with water (20 mL) and extracted into dichloromethane (2×40 mL). The combined organic layers were washed with saturated aqueous brine solution (2×40 mL), dried (MgSO4) and concentrated to afford 1-trifluoromethanesulfonyl-piperazine as a pale yellow solid (1.92 g, 76%).

1. customquenched with water (20 mL)
2. extractionextracted into dichloromethane (2×40 mL)
3. washThe combined organic layers were washed with saturated aqueous brine solution (2×40 mL)
4. dry with materialdried (MgSO4)
5. concentrationconcentrated