Potassium Carbonate → HCID 86619255, compound

HRID 2403394Notes

Reaction equation

HRID 2403394 reaction equation
Br[CH2:2][C:3]1[S:11][C:10]2[C:9]([N:12]3[CH2:17][CH2:16][O:15][CH2:14][CH2:13]3)=[N:8][C:7]([Cl:18])=[N:6][C:5]=2[CH:4]=1.[CH3:19][S:20]([N:23]1[CH2:28][C@@H:27]([CH3:29])[NH:26][C@@H:25]([CH3:30])[CH2:24]1)(=[O:22])=[O:21].C(=O)([O-])[O-].[K+].[K+]>C(#N)C>[Cl:18][C:7]1[N:8]=[C:9]([N:12]2[CH2:17][CH2:16][O:15][CH2:14][CH2:13]2)[C:10]2[S:11][C:3]([CH2:2][N:26]3[C@H:25]([CH3:30])[CH2:24][N:23]([S:20]([CH3:19])(=[O:22])=[O:21])[CH2:28][C@@H:27]3[CH3:29])=[CH:4][C:5]=2[N:6]=1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 461807264-(6-(Bromomethyl)-2-chlorothieno[3,2-d]pyrimidin-4-yl)morpholineHCID 66617827HCID 66617827, compound

Product 1

HCID 86619255HCID 86619255, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

Reaction between 6-(bromomethyl)-2-chloro-4-morpholinothieno[3,2-d]pyrimidine and (3S,5R)-1-methanesulfonyl-3,5-dimethyl-piperazine using potassium carbonate and acetonitrile yielded 2-chloro-6-((2S,6R)-4-methanesulfonyl-2,6-dimethyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine. This compound was subjected to procedure A to yield the desired final compound which was purified using flash chromatography.

Sources & evidence

ORD record
ord-e963beca4b234c8592a31758bfbb7305
Source dataset
uspto-grants-2014_08
Patent number
US08802670B2

Reaction notes

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