Hydrochloric Acid → 111247-63-3

HRID 2403439Notes

Reaction equation

HRID 2403439 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([CH2:14][N:15]2[CH2:19][CH2:18][CH2:17][C:16]2=[O:20])[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:21]>ClCCl.CCOCC>[ClH:21].[NH:8]1[CH2:9][CH2:10][CH:11]([CH2:14][N:15]2[CH2:19][CH2:18][CH2:17][C:16]2=[O:20])[CH2:12][CH2:13]1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 53722296HCID 53722296, compound

Product 1

HCID 21241491111247-63-3

Reagents, catalysts & solvents 2

HCID 3283Diethyl EtherSolventHCID 6344DichloromethaneSolvent

Procedure

To a solution of 4-(2-Oxo-pyrrolidin-1-ylmethyl)-piperidine-1-carboxylic acid tert-butyl ester in dichloromethane was added 2M hydrogen chloride in ether (1.78 ml). The reaction mixture was stirred at room temperature for 6 hours. The solvents were removed in vacuo to yield 1-Piperidin-4-ylmethyl-pyrrolidin-2-one hydrochloride salt.

Workup

  1. customThe solvents were removed in vacuo

Sources & evidence

ORD record
ord-156b1ededfa349bda72568b5da3877ca
Source dataset
uspto-grants-2014_08
Patent number
US08802670B2

Reaction notes

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