Iodoethane → HCID 58306199, compound

HRID 2403802Notes

Reaction equation

HRID 2403802 reaction equation
[CH2:1]([O:5][C:6]1[N:14]=[C:13]2[C:9]([N:10]=[C:11]([O:23][CH3:24])[N:12]2[CH2:15][CH2:16][CH:17]2[CH2:22][CH2:21][CH2:20][CH2:19][NH:18]2)=[C:8]([NH2:25])[N:7]=1)[CH2:2][CH2:3][CH3:4].[CH2:26](I)[CH3:27].CCN(C(C)C)C(C)C>CO>[CH2:1]([O:5][C:6]1[N:14]=[C:13]2[C:9]([N:10]=[C:11]([O:23][CH3:24])[N:12]2[CH2:15][CH2:16][CH:17]2[CH2:22][CH2:21][CH2:20][CH2:19][N:18]2[CH2:26][CH3:27])=[C:8]([NH2:25])[N:7]=1)[CH2:2][CH2:3][CH3:4]

Participants

5

Reactant 3

HCID 6340IodoethaneHCID 81531DiisopropylethylamineHCID 67183075HCID 67183075, compound

Product 1

HCID 58306199HCID 58306199, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A portion of the solution (3 ml) containing 2-(butyloxy)-8-(methyloxy)-9-[2-(2-piperidinyl)ethyl]-9H-purin-6-amine (approx 140 mg, 0.402 mmol) was treated with ethyl iodide (0.032 ml, 0.402 mmol) and DIPEA (0.140 ml, 0.804 mmol). The reaction was stirred at ambient temperature in a capped vial overnight. Methanol was added to give solution and this was purified by MDAP (Method A). Product fractions were evaporated under N2 in a Radleys blow down unit. The title compound was obtained as a white solid (103 mg).

Workup

  1. customto give solution
  2. customthis was purified by MDAP (Method A)
  3. customProduct fractions were evaporated under N2 in a Radleys blow down unit

Sources & evidence

ORD record
ord-f28d09510fd6425782af8dd5c1908cb2
Source dataset
uspto-grants-2014_08
Patent number
US08802684B2

Reaction notes

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