1-Iodopropane → 6-Amino-2-(butyloxy)-9-[2-(1-propyl-3-piperidinyl)ethyl]-7,9-dihydro-8H-purin-8-one

HRID 2403905Notes

Reaction equation

HRID 2403905 reaction equation
[CH2:1]([O:5][C:6]1[N:14]=[C:13]2[C:9]([N:10]=[C:11]([O:23]C)[N:12]2[CH2:15][CH2:16][CH:17]2[CH2:22][CH2:21][CH2:20][NH:19][CH2:18]2)=[C:8]([NH2:25])[N:7]=1)[CH2:2][CH2:3][CH3:4].I[CH2:27][CH2:28][CH3:29]>>[NH2:25][C:8]1[N:7]=[C:6]([O:5][CH2:1][CH2:2][CH2:3][CH3:4])[N:14]=[C:13]2[C:9]=1[NH:10][C:11](=[O:23])[N:12]2[CH2:15][CH2:16][CH:17]1[CH2:22][CH2:21][CH2:20][N:19]([CH2:27][CH2:28][CH3:29])[CH2:18]1

Participants

3

Reactant 2

HCID 336431-IodopropaneHCID 583062622-(Butyloxy)-8-(methyloxy)-9-[2-(3-piperidinyl)ethyl]-9H-purin-6-amine

Product 1

HCID 671801726-Amino-2-(butyloxy)-9-[2-(1-propyl-3-piperidinyl)ethyl]-7,9-dihydro-8H-purin-8-one

Procedure

Prepared similarly to Example 14 from 2-(butyloxy)-8-(methyloxy)-9-[2-(3-piperidinyl)ethyl]-9H-purin-6-amine and 1-iodopropane. LCMS (System A): tRET=0.69 min; MH+ 377

Workup

  1. custom=0.69 min

Sources & evidence

ORD record
ord-95a7ee885be040c6b1c4259df3c0a870
Source dataset
uspto-grants-2014_08
Patent number
US08802684B2

Reaction notes

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